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Cirrhosis (NASH/MASH) Clinical Research Study

Researchers are currently evaluating an investigational treatment for adults living with compensated cirrhosis caused by Metabolic Dysfunction-Associated Steatohepatitis (MASH), previously known as Nonalcoholic Steatohepatitis (NASH).

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If you have been diagnosed with fatty liver disease or cirrhosis, you may qualify to participate in an important clinical research study.

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See if you qualify today.

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What is MASH (Previously Known as NASH)?

Metabolic Dysfunction-Associated Steatohepatitis (MASH) is an advanced form of fatty liver disease caused by excess fat accumulation, inflammation, and scarring of the liver.

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As liver scarring progresses, it can eventually develop into cirrhosis, increasing the risk of serious liver complications.

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Many people have few or no symptoms during the early stages, making regular monitoring especially important

Common symptoms may include:

  • Fatigue

  • Weakness

  • Abdominal discomfort

  • Unexplained weight changes

  • Swelling in the abdomen or legs

  • Changes in liver blood test results

About This Research Study

The purpose of this clinical research study is to evaluate an investigational treatment designed for adults living with compensated cirrhosis caused by MASH.

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Researchers will monitor participants over time to better understand:

  • Liver health

  • Disease progression

  • Liver function

  • Overall safety

  • Quality of life

  • Long-term clinical outcomes

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Qualified participants will receive close medical monitoring throughout the study by experienced healthcare professionals. The study is randomized and placebo-controlled, meaning participants are assigned by chance to receive either the investigational treatment or placebo.

Do You Have Fatty Liver Disease?

Many people living with liver disease don't realize it until significant liver damage has already occurred.

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Fatty liver disease often develops silently over many years with few noticeable symptoms.

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As the condition progresses, it can lead to inflammation, scarring (fibrosis), and eventually cirrhosis, even if you still feel relatively well.

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If you've ever been told you have:

  • Fatty Liver

  • NASH

  • MASH

  • Liver Fibrosis

  • Liver Scarring

  • Cirrhosis

  • Elevated Liver Enzymes

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What is Compensated Cirrhosis?

Cirrhosis is advanced scarring of the liver.

Compensated cirrhosis means your liver has developed significant scar tissue but is still able to perform most of its normal functions.

Many people with compensated cirrhosis continue normal daily activities without realizing their liver disease has progressed.

Without proper monitoring, compensated cirrhosis may eventually progress to more serious liver complications.

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Risk Factors

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You may be at increased risk if you have:

  • Type 2 Diabetes

  • Obesity

  • High Cholesterol

  • High Blood Pressure

  • Metabolic Syndrome

  • Fatty Liver Disease

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These conditions commonly occur together and increase the risk of liver damage over time.

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Common Symptoms:

Many people experience no symptoms at all.

Others may notice:

  • Persistent fatigue

  • Low energy

  • Pain or discomfort on the right side of the abdomen

  • Unexplained weakness

  • Difficulty losing weight

  • Abnormal liver blood tests

  • Swelling in the abdomen or legs (later stages)

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If you've experienced any of these symptoms, discussing them with your healthcare provider is important.

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Who May Qualify?

You may qualify if you:

  • Are between 18 and 80 years of age

  • Have been diagnosed with compensated cirrhosis related to MASH/NASH

  • Have a history of fatty liver disease

  • Meet the study's medical and laboratory requirements

  • Are willing to attend scheduled study visits

  • Can provide informed consent

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Eligibility is determined only after a complete medical evaluation by the study team.

What Does Participation Include?

If you qualify, your participation may include:

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  • Medical history review

  • Physical examinations

  • Blood and urine testing

  • Liver health assessments

  • FibroScan® evaluations

  • Electrocardiograms (ECGs)

  • Imaging studies

  • Weekly study treatment

  • Regular follow-up visits

  • Ongoing safety monitoring

 

Study procedures are provided at no cost to qualified participants.

Why Participate?

Clinical research plays a critical role in developing future treatments for liver disease.

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Participation may provide:

  • Access to investigational care

  • Regular health evaluations

  • Close monitoring by experienced research professionals

  • The opportunity to contribute to future medical advances

  • Compensation for time and travel, if available

  • Participation is always voluntary.

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Your Safety Comes First

Every clinical research study follows strict ethical and regulatory guidelines designed to protect participants.

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Throughout the study, participants receive ongoing medical monitoring, regular laboratory testing, safety evaluations, and continuous oversight by qualified healthcare professionals. Independent safety committees also review study data throughout the trial.

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